To participate in
The PRECISION Study

You must

• Be 18 years of age or older
• Have had OA or RA for at least 6 months
• Have been prescribed regular medication for your OA or RA pain for at least 6 months
• Have or be at high risk for heart
  disease (for example, if you've had
  a heart attack, stroke, or have diabetes). Your doctor can tell you if you are at high risk for heart disease

Women who are able to have children must have been using adequate birth control since their last period. Adequate birth control must also be used during the study. Adequate birth control methods include "the pill," a patch or implant, an intrauterine device (IUD), or any barrier method combined with a spermicide.

People with RA who are taking a diseasemodifying antirheumatic drug (DMARD) such as methotrexate, hydroxychloroquine, gold, sulfasalazine, or azathioprine or an oral steroid such as prednisone must be taking the same drug for 3 months with no change in dose for 1 month.

You cannot participate in
The PRECISION Study if you

• Are pregnant or planning to become
  pregnant or are nursing a baby
• Have had a heart attack, stroke, heart surgery, or any major surgery within 3 months before joining the study
• Are scheduled to have surgery during the study
• Have been treated for ulcers within
  60 days prior to joining the study
• Have a history of intestinal blockage
  or gastric bleeding within 6 months
  prior to joining the study
• Have inflammatory bowel disease,
  active disease of the stomach,
  intestines, liver, kidney, a blood
  clotting disorder, or cancer
• Need and are taking more than 325 mg of aspirin each day

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

What is the Purpose of the Precision Study

The PRECISION Study is a research study that will compare 3 approved medicines commonly used to treat pain in people who have osteoarthritis (OA) or rheumatoid arthritis (RA).
The 3 medicines are

• Celecoxib (brand name Celebrex)
• Ibuprofen (brand names include Advil, Medipren, Motrin,and Nuprin)
• Naproxen (brand names include Aleve, Anaprox, Naprelan, and Naprosyn)

All 3 drugs are approved pain relievers called nonsteroidal anti-inflammatory drugs, or NSAIDs. Doctors refer to ibuprofen and naproxen as traditional NSAIDs, but they refer to Celebrexas a COX-2 inhibitor. That's because Celebrex blocks (or inhibits) a certain enzyme in the body called COX-2 that causes pain and inflammation.

Recently, there have been some questions raised about the safety of both COX-2–selective inhibitors and traditional NSAIDs in people who have or are at high risk for heart disease. The PRECISION Study will help answerthese questions. The study will help doctors know more about the long-term safety of these medicines on the heart. The PRECISION Study will help provide the information doctors need to choose the most appropriate pain reliever for their patients with OA or RA who have or are at high risk for heart disease.

To speak with one of our recruitment specialists about this or any of our studies call
702-893-8968